Here we go again.

The ongoing soap opera concerning Grey's Anatomy stars Katherine Heigl and T.R. Knight and their uncertain futures took another crazy turn today when their co-star, James Pickens, Jr., commented that both of them are indeed leaving the show.

"Yes, she is," Pickens said when asked if the former Emmy winner was checking out of Seattle Grace. "Wherever Katherine goes, I wish her nothing but the best."

And what about T.R. Knight? "He's going too," Pickens, who plays Dr. Richard Webber, Chief of Surgery, said. "He just wanted to pursue other career paths."

ABC isn't commenting, but according to Entertainment Weekly, sources close to the situation have said regarding Pickens' comments, he may have jumped the gun.

While it's true Heigl and Knight want out, ABC execs have yet to officially issue the actors - who are under contract for six seasons - any Get Out of Jail Free cards.

However, all indications are that it will happen. The only question is when.

"Right now, the whole thing is in the hands of their agents and ABC's lawyers," explains a Grey's Anatomy insider. "Something will probably be worked out soon."

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.