Long unhappy with Grey's Anatomy, cast members T.R. Knight and Katherine Heigl have both asked to be released from their contracts with the hit ABC drama, co-star James Pickens, Jr., reportedly says. While it has not gone down yet, it is only a question of when.

Or is it? Conflicting reports have had T.R. Knight asking to be let go for months now, but he hasn't budged. Meanwhile, Heigl's character, Izzie Stevens, has been the subject of more rumors than we can even count - most of which involve ghost-loving Izzie getting killed off.

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